Inventi Rapid: Med Chem

Inventi:prmc/20773/21

Synthesis and Antibacterial Activity of Novel Benzothiazole Based 1,3,4-Oxadiazole Derivatives

Heterocyclic compounds are widely distributed in nature and are essential for life. Many heterocyclic compounds due to their specific activity are employed in the treatment of many diseases. Heterocyclic compounds exhibit variety of biological activities. Benzothiazoles and 1,3,4-oxadiazole are well established in literature as important biologically active heterocyclic compounds. Benzothiazoles and 1,3,4-oxadiazole play a leading role in the treatment of a variety of bacterial infections. As part of ongoing studies in developing new antibacterial agent, a novel series of benzothiazole based 1,3,4-oxadiazole derivatives of 2-(Benzo[d]thiazole-2-oxymethyl)-5-(Aryl)-1,3,4-oxadiazole (III) was synthesized by sequencing reaction of 2-hydroxybenzothiazole with ethylchloroacetate, Pottasium carbonate, hydrazine derivatives and different aromatic acids. All the synthesized compounds were in good agreement with elemental and spectral data (FT-IR, 1H NMR and Mass spectroscopy). In-vitro antibacterial activity was evaluated against the two pathogenic bacterial strains, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram- negative) by agar diffusion method. The antibacterial activities were expressed as zone of inhibition in mm. The compounds have shown moderate activity. Compounds III a 2, III a 7 and III b 2 were found to be most active against Staphylococcus aureus and Compounds III a 4 and III b 2 were found to be most active against Escherichia coli....